CBD and DRUG interactions

Cannabis Safety Profile:

   Little is known about the safety of individual compounds. Serious adverse effects are rare with cannabis or its constituents.  Marijuana has low to moderate dependence potential; the active dose is very far below the lethal dose.

Drug Interactions Cytochrome P450 Enzymes: 

1. THC and CBD are metabolized by CYP3A4 and CYP2C9 
2. CYP3A4 inhibitors slightly increase THC levels.  
3. CYP3A4 inducers slightly decrease THC and CBD levels.  
4. CBD, but not THC, is metabolized by CYP2C19        

Drug Interaction Studies:

Warfarin: THC and CBD increase warfarin levels.

Alcohol: Alcohol may increase THC levels 

Theophylline: Smoked cannabis can decrease theophylline levels

Indinavir or nelfinavir: Smoked cannabis had no effect

Docetaxel or irinotecan: Cannabis infusion (tea) had no effect

Clobazam: In children treated with CBD for epilepsy, CBD increased clobazam levels

CNS depressants: Cannabis has additive CNS depressant effects with alcohol, barbiturates and benzodiazepines. In a small study, cannabis did not have additive CNS effects when combined with opioids

Studies have shown that CBD can interfere with blood pressure/blood thinning medication. 

Always consult with a professional.

Alternative Medicine CBD and Drug Interactions                                              

This article is for informational purposes only.